Key result
A-to-I RNA editing of neuronal receptors alters protein function and potentially impacts drug therapy.
A-to-I RNA editing alters the pharmacological properties of neuronal ion channels and receptors, potentially impacting drug therapy.
The regulation of neuronal excitability is complex, as ion channels and neurotransmitter receptors are underlying a large variety of modulating effects. Alterations in the expression patterns of receptors or channel subunits as well as differential splicing contribute to the regulation of neuronal excitability. RNA editing is another and more recently explored mechanism to increase protein diversity, as the genomic recoding leads to new gene products with novel functional and pharmacological properties. In humans A-to-I RNA editing targets several neuronal receptors and channels, including GluR2/5/6 subunits, the Kv1.1 channel, and the 5-HT(2C) receptor. Our review summarizes that RNA editing of these proteins does not only change protein function, but also the pharmacology and presumably the drug therapy in human diseases.
No takes yet. Share an insight, caveat, or question.
Streit et al. (2011) reported a review. A-to-I RNA editing was evaluated. A-to-I RNA editing of neuronal receptors and channels alters protein function and pharmacology, potentially impacting drug therapy in human diseases.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: