Factors Responsible For The Development Of Erythropoietin Resistance In Chronic Kidney Disease Patients

Chronic kidney disease (CKD) is a global socially significant health problem that now affects more than 10% of the world's population. Anemia is a common complication of CKD and is associated with reduced quality of life, increased morbidity and mortality, and higher treatment costs. Erythropoietin resistance is a common condition in the treatment of anemia in patients with CKD and is one of the most potent predictors of risk for cardiovascular events and mortality. The aim of the present study was to analyze some factors leading to the development of erythropoietin resistance in patients with chronic kidney disease. In 80 patients of the Clinic of Nephrology of St. Marina University Hospital, Varna, demographic indicators, levels of serum iron, folic acid, vitamin B12, iPTH, iFGF23, soluble erythropoietin receptor (sEPOR) and antiEPOab were studied.