Tubulopathy in Patients with Beta Thalassemia Major

The iron overload and the development of secondary hemosiderosis in patients with β-thalassemia major lead to organ damages, including kidney disorders from an early childhood. Contemporary urinary markers such as neutrophil gelatinase-association lipocalin, β2-microglobulin, and N-acetyl-β-D-glucosaminidase could be a useful tool for clinicians in diagnosing early tubular lesions. The current study was performed in 44 patients with β-thalassemia major and 30 controls. All participants were tested for NGAL, β2-MG, and NAG in the first sample morning urine using the ELISA method. The results showed statistically significant difference in urinary NGAL between the two examined groups. This marker indicates very early damage to the proximal tubule before cell death occurs.