What question did this study set out to answer?

To propose an updated, context-appropriate diagnostic algorithm for tuberculosis tailored to the low-incidence, high-resource settings of the European Union and European Economic Area.

November 20, 2025The Lancet Regional Health - EuropeOpen Access

Diagnostic algorithms for tuberculosis in Europe: insights from the European Reference Laboratory Network for Tuberculosis (ERLTB-Net)

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To propose an updated, context-appropriate diagnostic algorithm for tuberculosis tailored to the low-incidence, high-resource settings of the European Union and European Economic Area.
Synthesized regional epidemiological priorities and laboratory capacities through the European Reference Laboratory Network for Tuberculosis framework.
Adapted World Health Organization model algorithms to address regional diagnostic challenges regarding extensively drug-resistant tuberculosis.
Prioritizes universal initial screening using rapid molecular diagnostic tests alongside systematic mycobacterial culture.
Integrates whole genome sequencing and targeted next-generation sequencing with strategic phenotypic drug susceptibility testing to direct personalized therapy.
Identifies regional diagnostic harmonisation, cross-border surveillance, and sustained sequencing investment as critical requirements for tuberculosis control.

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Implication

Expert viewpoint proposes a tailored tuberculosis diagnostic algorithm in European settings, suggesting enhanced surveillance and genomic testing improve drug-resistant treatment outcomes.

Cite This Study

Saluzzo et al. (2025) studied this question.

synapsesocial.com/papers/6aa4ea1219fe908cf3aa1f90 https://doi.org/10.1016/j.lanepe.2025.101516

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Implication

Expert viewpoint proposes a tailored tuberculosis diagnostic algorithm in European settings, suggesting enhanced surveillance and genomic testing improve drug-resistant treatment outcomes.

Diagnostic algorithms for tuberculosis in Europe: insights from the European Reference Laboratory Network for Tuberculosis (ERLTB-Net)

Key Points

Discussion

Implication

Cite This Study

Diagnostic algorithms for tuberculosis in Europe: insights from the European Reference Laboratory Network for Tuberculosis (ERLTB-Net)

Key Points

Discussion

Implication

Cite This Study

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