Key result
HbA1c > 5.9% linked to ~140% higher risk of thick cIMT and high carotid plaque score.
Why the study?
What are the clinical and laboratory determinants of carotid intima media thickness and carotid plaque score in community-dwelling and non-diabetic individuals?
Cohort (n=331)
What are the clinical and laboratory determinants of carotid intima media thickness and carotid plaque score in community-dwelling and non-diabetic individuals?
HbA1c > 5.9% is a determinant of early and late stage subclinical atherosclerosis in community-dwelling individuals, highlighting its role as a risk marker even outside of overt diabetes.
HbA1c >5.9% may flag higher subclinical carotid atherosclerosis risk in communities; leaves open causality and need for interventional trials.
BACKGROUND: The carotid intima media thickness (cIMT) and carotid plaque score (cPS) are respective markers of early and late stage subclinical atherosclerosis. Relationships between some laboratory parameters and subclinical atherosclerosis are not yet clear in community dwelling individuals and non-diabetic subjects, so we try to elucidate these relationships and find a model to predict early and late stage subclinical atherosclerosis. METHODS: We examined relationships of the cIMT and cPS with different laboratory and demographic data of 331 subjects from a community-based prospective cohort study, using univariate and multivariate analyses. RESULTS: In regression models and after multiple adjustments, only systolic blood pressure (SBP), age, glycated hemoglobin (HBA1c), and waist circumference (WC) were determinants of the cIMT, and only age, SBP, HBA1c, and blood urea nitrogen (BUN) were determinants of a cPS of > 2 in all individuals. Only HBA1c lost its association with regard to predicting the cIMT in non-diabetic subjects. CONCLUSIONS: HBA1c at > 5.9% can determine early and late stage subclinical atherosclerosis in community dwelling individuals, but only late stage subclinical atherosclerosis in non-diabetic subjects.
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Alizargar et al. (2018) conducted a cohort in Subclinical atherosclerosis (n=331). Glycated hemoglobin (HBA1c) > 5.9% vs. HBA1c ≤ 5.9% was evaluated on Thick carotid intima media thickness (> 0.75 cm) (OR 2.396, 95% CI 1.224-4.690). In community-dwelling individuals, an HBA1c level > 5.9% was significantly associated with a higher risk of having a thick carotid intima media thickness (OR 2.396) and a high carotid plaque score.
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