Key result
In treated hypertensive patients, the presence of diabetes mellitus was associated with a significantly higher intima-media thickness of the common carotid artery (1.025 vs 0.928 mm, p=0.04).
Cross-Sectional (n=56)
No
Absolute Event Rate: 1.025% vs 0.928%
p-value: p=0.04
In treated hypertensive patients, HbA1c levels are independently associated with both morphological (IMT) and hemodynamic (RI) markers of carotid atherosclerosis.
DM presence may flag higher carotid atherosclerosis risk in treated hypertensives; extends observational links but leaves causal role of glycemia open.
Objectives: To evaluate factors influencing resistive index (RI) and intima-media thickness of common carotid artery (IMT-CCA) as indices of arterial atherosclerosis in hypertensive patients.Methods: 56 treated hypertensive outpatients (mean age 68.9 Æ 9.7 years; 31 diabetics) were examined.Fasting blood glucose, cholesterol, and HbA 1c concentration and glomerular filtration rate were measured.Systolic (SBP), diastolic blood pressure (DBP) and pulse pressure were estimated during ambulatory blood pressure monitoring.Ultrasonography of the CCA was performed with determination of IMT-CCA and RI.Results: With diabetes IMT-CCA was significantly (1.025 Æ 0.17 vs 0.928 Æ 0.18 mm, p Z 0.04) and RI not significantly (0.71 Æ 0.06 vs 0.68 Æ 0.08, p Z 0.07) higher.A correlation between HbA 1c and RI, IMT-CCA and the age was found.After dividing the whole group into subgroups corresponding to the tertiles of HbA 1c levels, mean IMT-CCA values in I and II tertile were significantly lower than in III tertile (p Z 0.008 and p Z 0.002 respectively), while RI was significantly higher in III tertile than in I tertile (p Z 0.03).On multiple regression analysis IMT-CCA was significantly influenced by the age (b Z 0.343, p Z 0.04), SBP (b Z 0.430, p Z 0.03) and HbA 1c (b Z 0.369, p Z 0.01), while RI was influenced by SBP (b Z 0.696, p Z 0.0006), DBP (b Z À0.618, p Z 0.003) and HbA 1c (b Z 0.279, p Z 0.04).Conclusion: Patients with hypertension and diabetes mellitus had significantly increased IMT and not significantly higher RI.Concentration of HbA 1c , next to the age, SBP and DBP values was independently associated with IMT-CCA and RI e parameters determining indirectly the degree of atherosclerosis of common carotid artery.
No takes yet. Share an insight, caveat, or question.
Skalska et al. (2010) conducted a cross-sectional in Arterial hypertension (n=56). Diabetes mellitus vs. Absence of diabetes mellitus was evaluated on Intima-media thickness of common carotid artery (IMT-CCA) (p=0.04). In treated hypertensive patients, the presence of diabetes mellitus was associated with a significantly higher intima-media thickness of the common carotid artery (1.025 vs 0.928 mm, p=0.04).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: