Key result
Higher carotid resistive index (top quartile) was associated with a higher prevalence of left ventricular hypertrophy and peripheral artery disease compared with low resistive index (p < 0.05).
Why the study?
Does carotid resistive index correlate with target organ damage in treated hypertensive patients?
Cross-Sectional (n=265)
Does carotid resistive index correlate with target organ damage in treated hypertensive patients?
p-value: p=<0.05
Carotid resistive index is independently associated with target organ damage, including left ventricular hypertrophy and peripheral artery disease, in treated hypertensive patients.
May support carotid resistive index for target organ damage assessment in hypertension; hypothesis-generating and should not yet change practice.
AIM: The resistive index (RI) is a hemodynamic parameter that reflects local wall extensibility and related vascular resistance. We analyze the relationship between common carotid RI and target organ damage in treated hypertensive patients. METHODS: We analyzed 265 consecutive hypertensive patients. Risk factors, cardiovascular history and treatments were collected; blood test, urinary albumin excretion (UAE), echocardiography to determine left ventricular mass index (LVMI), ankle-brachial index (ABI) and carotid echo-Doppler ultrasound to calculate the carotid intima-media thickness (IMT) and RI of both common carotids arteries were performed. RESULTS: A positive correlation was found between carotid RI and age, systolic blood pressure, heart rate, carotid IMT, LVMI, UAE and a negative correlation was found with diastolic blood pressure and ABI. Subjects at the top quartile of carotid RI showed a higher prevalence of left ventricular hypertrophy and peripheral artery disease (increased IMT, carotid plaques and lower ABI) compared with those with low RI (p < 0.05). Multiple regression analysis demonstrated that age, systolic and diastolic blood pressure and LVMI independently influence carotid RI. CONCLUSION: Carotid RI is related with age, systolic-diastolic blood pressure and LVMI in hypertensive patient. This evaluation could predict the presence of early cardiovascular damage and provide an accurate estimation of overall risk in this population.
No takes yet. Share an insight, caveat, or question.
Morillas et al. (2012) conducted a cross-sectional in Hypertension (n=265). High carotid resistive index vs. Low carotid resistive index was evaluated on Target organ damage (left ventricular hypertrophy and peripheral artery disease) (p=<0.05). Higher carotid resistive index (top quartile) was associated with a higher prevalence of left ventricular hypertrophy and peripheral artery disease compared with low resistive index (p < 0.05).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: