Key result
Carotid IMT correlates positively with systolic BP, age, and cholesterol in hypertensive patients.
Why the study?
Carotid intima-media thickness was proposed as an intermediate marker of target organ damage and predictor of stroke and myocardial infarction, prompting evaluation of its relationship with other cardiovascular risk factors in essential hypertension.
Cross-Sectional (n=77)
Answers are grounded in this paper and cite their sources.
In patients with mild-to-moderate essential hypertension, carotid intima-media thickness is significantly associated with systolic blood pressure, age, lipid levels, and cardiac structural remodeling.
Objective: Carotid intima-media thickness (CIMT) was proposed as intermediate marker of target organ damage and predictor of stroke and myocardial infarction. We evaluate relationship between CIMT and other cardiovascular diseases risk factors in 77 pts with mild and moderate essential hypertension(EH),average age 58,7 ± 1,2. Design, Methods: The study protocol included: measurement of office BP, blood lipids, glucose, creatinine, uric acid. CIMT was measured by ultrasonography, left ventricular values by Doppler echocardiography. Results: There were found increase of IMT >0.9 mm in 33,8% pts, carotid artery stenosis >20% in 55,8% pts with EH. We observed significant correlation of IMT with systolic BP (r = 0,35, p = 0,003),pulse pressure (PP) (r = 0,33, p = 0,005) and age(r = 0,35, p = 0,003), between IMT and the left atrium(LA) size (r = 0,30, p = 0,01), and the left ventricular ejection fraction (LVEF)(r = 0,20,p = 0,05). In subgroup of pts with IMT > 0.9 mm (1st group) there were reliably higher levels of systolic BP, PP, LA size, the left ventricle internal end-diastolic diameter (LVIDD), total and LPLD cholesterol level (tab). We found the significant interrelation of IMT with LVIDD (r = 0,25, p = 0,01x10-6), LVIDS(r = 0,56, p = 0,01x10-4), and LVEF(r = 0,31, p = 0,01x10-7). IMT tightly correlated with the level of total cholesterol and LPLD cholesterol (r = 0,66, p = 0,01x10-7; r = 0,73, p = 0,003, respectively), and also with the content of creatinine (r = 0,83, p = 0,01x10-8) in the 1st group pts. By the standardized regression analysis increase in IMT was associated predominantly with lipid exchanges: coefficients β of IMT with total cholesterol was 0,297,p = 0,042 in the 1st gr.pts. For pts with IMT < 0.9 mm the age and systolic BP had more significant influence on IMT: coefficients β were 0,593, p = 0,0001 and 0,456, p = 0,002 respectively. Conclusions: At the elastic common carotid artery IMT changes is related with BP elevation, in part with pulsatile component of BP (SBP,PP) and with age. The vessel wall thickening is associated with total cholesterol level elevation and IMT >0.9 mm may be a marker of atherosclerosis. There are significant correlations between heart and vessels damage in hypertensive patients.
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Yarynkina et al. (2010) conducted a cross-sectional in Mild and moderate essential hypertension (n=77). Cardiovascular risk factors (BP, lipids, age, creatinine) and echocardiographic parameters vs. Subgroup comparison between patients with carotid IMT >0.9 mm and IMT <0.9 mm was evaluated on Carotid intima-media thickness (CIMT) and its correlation with cardiovascular risk factors and left ventricular parameters (r 0.35, p=0.003). Carotid IMT correlated significantly with systolic BP (r=0.35, p=0.003), age (r=0.35, p=0.003), and total cholesterol (r=0.66, p=0.01x10^-7 in IMT >0.9 mm subgroup) in hypertensive patients.
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