Key result
Pulse pressure, HDL-C, and CRP are independently linked to increased carotid IMT in hypertensive women.
Why the study?
Do pulse pressure, HDL-cholesterol, and C-reactive protein independently correlate with increased carotid intima-media thickness in treated middle-aged hypertensive women?
Cross-Sectional (n=116)
No
Do pulse pressure, HDL-cholesterol, and C-reactive protein independently correlate with increased carotid intima-media thickness in treated middle-aged hypertensive women?
Elevated pulse pressure, high CRP, and low HDL-cholesterol are independently associated with subclinical atherosclerosis in hypertensive women, identifying potential parameters for clinical risk stratification.
Answers are grounded in this paper and cite their sources.
May aid risk stratification in treated hypertensive women; leaves open causal role and need for prospective outcome trials.
It has been previously documented that carotid intima-media thickness (cIMT) is a predictor of cardiovascular disease. The aim of this study was to identify clinical parameters associated with an increased cIMT treated hypertensive women. Female patients (n = 116) with essential hypertension, aged 40-65 years, were included in this study. Vascular ultrasound was performed and the patients were divided into two groups according to the values of cIMT (< or ≥0.9 mm). Patients with greater cIMT presented significantly higher systolic blood pressure and pulse pressure. Serum HDL-cholesterol was significantly lower and CRP was significantly higher in the same group. There was a significant correlation between cIMT and age (r = 0.25, P = 0.007), systolic blood pressure (r = 0.19, P = 0.009), pulse pressure (r = 0.30, P = 0.001), and LDL-cholesterol (r = 0.19, P = 0.043). cIMT was correlated to CRP (r = 0.31, P = 0.007) and negatively correlated to HDL-cholesterol (r = 0.33, P = 0.001). In logistic regression, only HDL-cholesterol, CRP, and pulse pressure were shown to be independent variables associated to increased cIMT. In conclusion, pulse pressure, HDL-cholesterol, and CRP are variables correlated with cIMT in treated hypertensive women.
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Trindade et al. (2012) conducted a cross-sectional in Essential hypertension (n=116). Increased carotid intima-media thickness (≥0.9 mm) vs. Carotid intima-media thickness <0.9 mm was evaluated on Independent clinical variables associated with increased carotid intima-media thickness. Pulse pressure, HDL-cholesterol, and C-reactive protein were shown to be independent variables associated with increased carotid intima-media thickness in treated hypertensive women.
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