Vascular wall elasticity measurement by magnetic resonance imaging
Key result
MRI-based elastography shows preliminary feasibility for quantitatively assessing blood vessel stiffness and measuring stenosis.
Why the study?
Can MRI-based elastography (MRE) quantitatively assess the stiffness of blood vessels and measure stenosis in vessel models and in vivo human arteries?
Population
Thin-walled latex vessel model, ex vivo porcine models, and in vivo human arteries
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Supports MRE development for vascular stiffness assessment; leaves open clinical translation pending human validation.
Structured PICO
Can MRI-based elastography (MRE) quantitatively assess the stiffness of blood vessels and measure stenosis in vessel models and in vivo human arteries?
P
Population
Thin-walled latex vessel model, ex vivo porcine models, and in vivo human arteries
I
Intervention
MRI-based elastography (MRE)
O
Outcome
Ability to measure Young's modulus-wall thickness product, quantitate degree of stenosis, and assess stiffness of blood vesselssurrogate
MRI-based elastography shows preliminary feasibility for quantitatively assessing blood vessel stiffness and measuring stenosis non-morphologically.
Limitations
- Requires further development before it can be fully implemented in vivo
Cite This Study
Woodrum et al. (2006) studied Vascular stiffness and stenosis. MRI-based elastography (MRE) was evaluated on Feasibility of measuring elastic properties of vessel walls and quantitatively assessing stenotic lesions. MRI-based elastography (MRE) demonstrated preliminary feasibility for quantitatively assessing blood vessel stiffness and providing a non-morphologic method to measure stenosis.