Key result
Higher cardio-ankle vascular index is linked to ~200% greater silent neuronal injury risk post-PCI in ACS.
Why the study?
Does the cardio-ankle vascular index (CAVI) predict silent neuronal injury after percutaneous coronary angiography and intervention in patients with ACS?
Observational (n=83)
Does the cardio-ankle vascular index (CAVI) predict silent neuronal injury after percutaneous coronary angiography and intervention in patients with ACS?
CAVI may serve as a useful non-invasive marker for predicting silent neuronal injury following percutaneous coronary interventions in ACS patients.
Answers are grounded in this paper and cite their sources.
CAVI may identify higher-risk ACS patients for silent injury post-PCI; leaves open prospective validation before clinical adoption.
OBJECTIVE: The relationship between silent neuronal injury (SNI) and arterial stiffness assessed by cardio-ankle vascular index (CAVI) has not been evaluated in patients treated with coronary angiography and intervention due to acute coronary syndrome (ACS). The aim of this study is to evaluate the value of CAVI in prediction of SNI after percutaneous coronary angiography and intervention in patients presented with ACS. METHODS: Eighty-three consecutive patients presented with ACS, who underwent percutaneous coronary angiography and intervention, were included in this prospective observational study on diagnostic accuracy. Neuron specific enolase (NSE) was studied before and 18 hour after the coronary angiography and intervention. CAVI was measured by VaSera-1000 instrument. Clinical and echocardiographic characteristics were analyzed and independent predictors of SNI were evaluated. Chi-square, Student t-test, Mann-Whithney U test, correlation analysis and logistic regression analysis was used for statistical analysis. RESULTS: NSE levels significantly increased after cardiac catheterization (9.82±3.22 mg/dL vs. 13.15±8.55 mg/dL, p<0.001). CAVI (OR=2.992, 95% CI: 1.494-5.713, p=0.002), left ventricular ejection fraction (LVEF) (OR=0.911, 95% CI: 0.843-0.983, p=0.017) and undergoing percutaneous coronary intervention (OR=4.430, 95% CI: 1.034-18.97, p=0.045) were the independent predictors of SNI in logistic regression analysis. The cut-off value to show SNI for CAVI was 10.45 (sensitivity=71.8%, specificity=91.5%) in receiver operator charecteristic (ROC) curve analysis. The area under curve was 0.832 (95% CI=0.746-0.918, p<0.001). CONCLUSION: Besides undergoing PCI and having LVEF, measurement of CAVI may be a useful tool for predicting the development of SNI after percutaneous coronary angiography and intervention in patients with ACS.
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Aykan et al. (2014) conducted an observational in Acute coronary syndrome (n=83). Cardio-ankle vascular index (CAVI) was evaluated on Silent neuronal injury (SNI) (OR 2.992, 95% CI 1.494-5.713, p=0.002). Cardio-ankle vascular index was an independent predictor of silent neuronal injury after percutaneous coronary angiography and intervention in patients with ACS (OR 2.992; 95% CI 1.494-5.713; p=0.002).
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