Key result
Euglycemic insulin clamp induces a 2.5 mEq/L potassium nadir and paralysis in hypokalemic periodic paralysis.
Why the study?
Does insulin-mediated extra-renal potassium disposal play a role in the clinical syndrome of hypokalemic periodic paralysis?
Case Report (n=26)
Does insulin-mediated extra-renal potassium disposal play a role in the clinical syndrome of hypokalemic periodic paralysis?
Absolute Event Rate: 2.5% vs 3.3%
Insulin can induce severe hypokalemia and paralysis in familial hypokalemic periodic paralysis despite coexistent obesity-related insulin resistance for glucose utilization.
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Insulin may provoke paralysis in hypokalemic periodic paralysis; leaves open its mechanistic role pending controlled studies.
Minaker et al. (1988) conducted a case report in familial hypokalemic periodic paralysis (n=26). Euglycemic insulin clamp vs. Normal and obese control subjects was evaluated on Plasma potassium nadir during high-dose insulin infusion. High-dose euglycemic insulin clamp induced a significantly lower plasma potassium nadir (2.5 meq/liter) and paralysis in a patient with hypokalemic periodic paralysis compared to controls.
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