Key result
Pinacidil (25 mg orally) had no effect on insulin secretion in patients with hypokalaemic periodic paralysis or controls, but increased muscle strength in patients with baseline weakness (<150 N).
Why the study?
Does pinacidil improve insulin release and muscle strength in patients with hypokalaemic periodic paralysis during hyperglycaemia?
RCT (n=12)
Double-blind
Does pinacidil improve insulin release and muscle strength in patients with hypokalaemic periodic paralysis during hyperglycaemia?
Pinacidil does not affect insulin secretion but may enhance muscle strength in hypokalaemic periodic paralysis patients with partial paralytic attacks.
No takes yet. Share an insight, caveat, or question.
Pinacidil should not be used to boost insulin secretion; leaves open a potential role for muscle strength gains in patients with baseline weakness.
Ligtenberg et al. (1996) conducted an RCT in Hypokalaemic periodic paralysis (n=12). Pinacidil vs. Placebo was evaluated on Insulin release and muscle strength. Pinacidil (25 mg orally) had no effect on insulin secretion in patients with hypokalaemic periodic paralysis or controls, but increased muscle strength in patients with baseline weakness (<150 N).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: