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June 1, 1975Archives of Neurology

In patients with hypokalemic periodic paralysis, acetazolamide reduced the glucose and insulin-induced fall in serum K+ from 1.9 mM to 0.9 mM.

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Why the study?

Does acetazolamide reduce the fall in serum K+ induced by glucose and insulin in patients with hypokalemic periodic paralysis?

Population

3 patients with hypokalemic periodic paralysis and normal persons

Comparison

Acetazolamide 250 mg four times daily vs Baseline and normal persons

Design

Case_series

Authors

FVFrederic Q. Vroom

Discussion

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Overview

May support acetazolamide for K+ stabilization in hypokalemic periodic paralysis; leaves open effects on attack frequency.

Structured PICO

Does acetazolamide reduce the fall in serum K+ induced by glucose and insulin in patients with hypokalemic periodic paralysis?

P
Population
3 patients with hypokalemic periodic paralysis and normal persons
I
Intervention
Acetazolamide 250 mg four times daily
C
Comparator
Baseline (prior to acetazolamide) and normal persons
O
Outcome
Change in serum K+ following administration of glucose and insulinsurrogate

Acetazolamide ameliorates symptoms and reduces the pathological entry of potassium into muscle cells during attacks of hypokalemic periodic paralysis by inducing metabolic acidosis.

Cite This Study

Frederic Q. Vroom (1975) studied this question.

synapsesocial.com/papers/6a7c903365c70251ff7709ebhttps://doi.org/10.1001/archneur.1975.00490480051006
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Acetazolamide Treatment of Hypokalemic Periodic Paralysis1970 · 134 citations
  2. 2EFFECT UPON SERUM INSULIN, GLUCOSE AND POTASSIUM CONCENTRATIONS OF ACETAZOLAMIDE DURING ATTACKS OF FAMILIAL PERIODIC HYPOKALEMIC PARALYSIS2009 · 19 citations
  3. 3Acetazolamide Prophylaxis in Hypokalemic Periodic Paralysis1968 · 86 citations
  4. 4Acetazolamide opens the muscular K Ca 2+ channel: A novel mechanism of action that may explain the therapeutic effect of the drug in hypokalemic periodic paralysis2000 · 77 citations
  5. 5Hypokalemic periodic paralysis exacerbated by acetazolamide1981 · 49 citations