Why the study?
Does triamterene prevent paralytic attacks in patients with hypokalemic periodic paralysis exacerbated by acetazolamide?
Population
3 patients (a father and two sons) with hypokalemic periodic paralysis exacerbated by acetazolamide
Comparison
Triamterene vs Acetazolamide
Design
Case_series, single-blind
Follow-up
more than 12 months
Authors
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May warrant trial in acetazolamide-exacerbated cases; hypothesis-generating and requires randomized confirmation.
Does triamterene prevent paralytic attacks in patients with hypokalemic periodic paralysis exacerbated by acetazolamide?
Triamterene may be an effective treatment for patients with hypokalemic periodic paralysis who experience exacerbations with acetazolamide.
Torres et al. (1981) studied this question.