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July 1, 1970Annals of Internal Medicine

10 of the 12 patients were dramatically improved by acetazolamide, maintaining response for 16 to 43 months.

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Why the study?

Does acetazolamide improve attacks of weakness in patients with hypokalemic periodic paralysis?

Population

12 patients with hypokalemic periodic paralysis

Comparison

Acetazolamide vs Placebo

Design

RCT

Follow-up

16 to 43 months

Authors

RGRobert C. Griggs

Discussion

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Overview

Acetazolamide should be considered for hypokalemic periodic paralysis; supports first-line use from this RCT.

Structured PICO

Does acetazolamide improve attacks of weakness in patients with hypokalemic periodic paralysis?

P
Population
12 patients with hypokalemic periodic paralysis
I
Intervention
Acetazolamide
C
Comparator
Placebo
O
Outcome
Improvement in attacks of weakness

Acetazolamide is highly effective in preventing attacks and improving interattack weakness in patients with hypokalemic periodic paralysis.

Cite This Study

Robert C. Griggs (1970) studied this question.

synapsesocial.com/papers/6a9041ec55a9abd3b0840b1dhttps://doi.org/10.7326/0003-4819-73-1-39
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Acetazolamide Prophylaxis in Hypokalemic Periodic Paralysis1968 · 86 citations
  2. 2Acetazolamide Treatment of Hypokalemic Periodic Paralysis1975 · 45 citations
  3. 3Hypokalemic periodic paralysis exacerbated by acetazolamide1981 · 49 citations
  4. 4EFFECT UPON SERUM INSULIN, GLUCOSE AND POTASSIUM CONCENTRATIONS OF ACETAZOLAMIDE DURING ATTACKS OF FAMILIAL PERIODIC HYPOKALEMIC PARALYSIS2009 · 19 citations
  5. 5Effects of acetazolamide on myotonia1978 · 69 citations