Key result
Antisera against recombinant MBP-related protein detect ~25 kDa proteins suggesting a role in CNS self-tolerance.
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The expression of MBP-related proteins in immune system tissues may be important for self-tolerance to CNS MBPs and the initiation of immune-associated demyelinating diseases.
Brain and immune system tissues express myelin basic protein (MBP) mRNAs that contain novel exons upstream of those of the classic MBPs. We have generated antisera against a recombinant protein that includes the deduced sequence for one of the predicted species of the new MBP-related protein, hemopoietic HMBPR1. We report here the presence of multiple proteins reactive to the antisera in a range of tissues. The principal finding is that the antisera recognize a family of proteins of approximately 25 kDa that are restricted to brain, thymus, and spleen, the only tissues in which the new MBP-related transcripts are present. These antisera also detect other proteins of apparent molecular mass consistent with other isoforms of predicted MBP-related proteins. The expression of MBP-related proteins in immune system tissues may be important for self-tolerance to CNS MBPs and the initiation of immune-associated demyelinating diseases.
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Kalwy et al. (1998) studied this question. Antisera against recombinant hemopoietic HMBPR1 was evaluated on Presence of MBP-related proteins in tissues. Antisera against a recombinant MBP-related protein recognized a family of ~25 kDa proteins restricted to mouse brain, thymus, and spleen, suggesting a role in self-tolerance to CNS MBPs.
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