Key result
Multiple amino acid replacements in FMDV epitopes show additive and non-additive effects on antibody recognition.
Population
Synthetic peptides mimicking the main antigenic site of foot-and-mouth disease virus of serotype C and…
Design
Preclinical
Authors
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Context-dependent epitope effects in FMDV may limit antigenic divergence; leaves open generalization to other RNA viruses.
The role of a single amino acid on antibody recognition depends on the sequence context, and non-additive effects of multiple replacements may modulate antigenic diversification of highly variable RNA viruses.
Mateu et al. (1992) studied Foot-and-mouth disease virus (FMDV) antigen recognition. Single and multiple amino acid replacements in synthetic peptides vs. Unmodified synthetic peptides was evaluated on Antigen specificity and antibody recognition. Multiple amino acid replacements in continuous B cell epitopes of foot-and-mouth disease virus exhibit both additive and non-additive effects on antibody recognition.
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