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Treatment of Spicaria elegans with cytochrome P-450 inhibitor resulted in two new deoxy-cytochalasins, 7-deoxy-cytochalasin Z 7 (1) and 7-deoxy-cytochalasin Z 9 (2), which were recognized as plausible precursors of cytochalasins Z 7 and Z 9 , respectively. Their structures were elucidated by spectroscopic methods and the absolute configuration of 1 was determined by the conventional Mosher ester method. Their cytotoxicities against two cancer cell lines were evaluated.
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Lin et al. (2009) studied this question.
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