Key result
HCV prevalence is up to ~4-fold higher in HCM and DCM patients versus blood donors.
Why the study?
Is Hepatitis C virus infection associated with a higher prevalence of cardiomyopathies?
Population
697 patients with hypertrophic cardiomyopathy, 663 patients with dilated cardiomyopathy, and 11,967 patients…
Comparison
Hepatitis C virus infection vs Volunteer blood donors in Japan (aged 50-59 years)
Design
Cross-sectional
Authors
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HCV infection was associated with cardiomyopathy; hypothesis-generating for etiologic role, should not yet change practice.
Cross-Sectional (n=13,327)
Yes
Is Hepatitis C virus infection associated with a higher prevalence of cardiomyopathies?
Absolute Event Rate: 10.6% vs 2.4%
p-value: p=<0.0001
HCV infection is significantly more prevalent in patients with hypertrophic and dilated cardiomyopathies compared to the general population, suggesting a potential etiologic link.
Matsumori et al. (1998) conducted a cross-sectional in Cardiomyopathies and other heart diseases (n=13,327). Cardiomyopathy (hypertrophic and dilated) vs. Volunteer blood donors was evaluated on Prevalence of Hepatitis C virus antibody (p=<0.0001). Hepatitis C virus (HCV) infection was significantly more prevalent in patients with hypertrophic (10.6%) and dilated (6.3%) cardiomyopathy than in volunteer blood donors (2.4%, p<0.0001).
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