What is the clinical evidence from this study?

Study design: Other. Population: S-A nodal pacemaker activity (n=10). Intervention: Caffeine. Primary outcome: Chronotropic response (heart rate acceleration).

What does this research mean for the field?

Caffeine administration to the sinoatrial node induces a double-peaked positive chronotropic response, characterized by an initial direct non-catecholaminergic acceleration followed by a sustained acceleration mediated by excitation of local adrenergic fibers and catecholamine release. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

January 1, 1972The Tohoku Journal of Experimental MedicineOpen Access

Double Peaked Positive Chronotropic Response of the Isolated Blood-perfused S-A Node to Caffeine

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Key result

Caffeine induces a double-peaked chronotropic response in canine SA nodes, secondary phase inhibited by beta-blockers.

n=10

Population

Isolated canine right atrium containing the S-A node area, perfused via the sinus node artery with blood…

Comparison

Selective administration of caffeine into the… vs Administration of caffeine in the presence of…

Design

Preclinical

Authors

SCShigetoshi ChibaMount Sinai Hospital KKKatsumi KubotaSaitama Medical University Hospital KHKeitaro HashimotoTokyo Institute of Technology

Discussion

Member takes

Implication

Caffeine may exert direct biphasic effects on sinoatrial automaticity; leaves open translation to human heart rate responses or clinical caffeine use.

Structured PICO

Population

10 mongrel dogs weighing 8 to 15 kg whose excised right atria were perfused to study the effects of caffeine on S-A nodal pacemaker activity.

Intervention

Selective administration of caffeine (100 μg to 1 mg) into the sinus node artery

Comparator

Administration of caffeine in the presence of adrenergic beta-blocking agents (alprenolol, propranolol) or tetrodotoxin

Outcome

Chronotropic response of the S-A nodesurrogate

Caffeine induces a biphasic positive chronotropic response in the canine S-A node, with the secondary phase mediated by local catecholamine release.

Cite This Study

Chiba et al. (1972) studied S-A nodal pacemaker activity (n=10). Caffeine was evaluated on Chronotropic response (heart rate acceleration). Caffeine administration into the sinus node artery of isolated canine right atria induced a double-peaked positive chronotropic response, with the secondary phase inhibited by beta-blockers or tetrodotoxin.

synapsesocial.com/papers/6aa5705f6cd58dd9e9f4c856 https://doi.org/10.1620/tjem.107.101

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January 1, 1972The Tohoku Journal of Experimental MedicineOpen Access

Double Peaked Positive Chronotropic Response of the Isolated Blood-perfused S-A Node to Caffeine

View Full Paper

Ask AI

Bookmark

Key result

Caffeine induces a double-peaked chronotropic response in canine SA nodes, secondary phase inhibited by beta-blockers.

n=10

Population

Isolated canine right atrium containing the S-A node area, perfused via the sinus node artery with blood…

Comparison

Selective administration of caffeine into the… vs Administration of caffeine in the presence of…

Design

Preclinical

Authors

SCShigetoshi ChibaMount Sinai Hospital KKKatsumi KubotaSaitama Medical University Hospital KHKeitaro HashimotoTokyo Institute of Technology

Discussion

Member takes

Implication

Caffeine may exert direct biphasic effects on sinoatrial automaticity; leaves open translation to human heart rate responses or clinical caffeine use.

Structured PICO

Population

10 mongrel dogs weighing 8 to 15 kg whose excised right atria were perfused to study the effects of caffeine on S-A nodal pacemaker activity.

Intervention

Selective administration of caffeine (100 μg to 1 mg) into the sinus node artery

Comparator

Administration of caffeine in the presence of adrenergic beta-blocking agents (alprenolol, propranolol) or tetrodotoxin

Outcome

Chronotropic response of the S-A nodesurrogate

Caffeine induces a biphasic positive chronotropic response in the canine S-A node, with the secondary phase mediated by local catecholamine release.

Cite This Study

synapsesocial.com/papers/6aa5705f6cd58dd9e9f4c856 https://doi.org/10.1620/tjem.107.101

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

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