Key result
Deleting the Pit-1 binding site in the human renin promoter reduces gene activity several-fold.
Population
Pituitary GC cells, primary or early passage cell cultures of placental chorionic membranes, and the…
Comparison
Transfection with human renin promoter-driven… vs Deletion or mutagenesis of the Pit-1 site
Design
Preclinical
Authors
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Pit-1 site may modulate renin across tissues; leaves open any clinical or therapeutic relevance in humans.
The Pit-1 binding site in the human renin gene promoter is crucial for directing renin gene expression in pituitary, placental, and juxtaglomerular cells.
Catanzaro et al. (1994) studied Renin gene expression. Deletion or mutagenesis of the Pit-1 binding site vs. Wild-type Pit-1 binding site was evaluated on Renin promoter-driven reporter gene activity. Deletion or mutagenesis of the Pit-1 binding site in the human renin gene promoter reduced reporter gene activity several-fold in pituitary, placental, and renal cells.
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