What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Hypertension (n=128). Intervention: Morisky and MARS-5 questionnaires vs. Medication possession ratio (MPR). Primary outcome: Validity (sensitivity, specificity, positive likelihood ratio) of adherence questionnaires compared to MPR.

What does this research mean for the field?

The Morisky and MARS-5 questionnaires demonstrate poor sensitivity for measuring adherence to antihypertensive drugs in primary care compared to the medication possession ratio. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

April 2, 2009Journal of Evaluation in Clinical Practice

Drug‐adherence questionnaires not valid for patients taking blood‐pressure‐lowering drugs in a primary health care setting

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Key result

Morisky and MARS-5 questionnaires demonstrate low sensitivity for measuring antihypertensive adherence vs MPR.

n=128

Why the study?

Are the Morisky and MARS-5 questionnaires valid for measuring adherence to antihypertensive drugs compared to medication possession ratio in primary care?

Population

128 patients using blood-pressure-lowering medication for at least 12 months in primary care in Germany…

Comparison

Morisky and Medication Adherence Report Scale… vs Medication possession ratio calculated from…

Design

Cross-sectional

Authors

NSNina Van De SteegRadboud University Nijmegen MSMartin SielkRegional Health MPMichael PentzekInstitut der Feuerwehr Nordrhein-Westfalen

Discussion

Member takes

Implication

Questionnaires' low sensitivity cautions against clinical reliance for adherence; leaves open need for validated tools versus objective measures in primary care.

Study Design

Type

Cross-Sectional (n=128)

Multicenter

Yes

Structured PICO

Are the Morisky and MARS-5 questionnaires valid for measuring adherence to antihypertensive drugs compared to medication possession ratio in primary care?

Population

128 primary care patients (mean age 71, 52% female) taking blood-pressure-lowering medication for at least 12 months.

Exposure

Morisky and Medication Adherence Report Scale (MARS-5) questionnaires

Comparator

Medication possession ratio (MPR) calculated from general practitioners' electronic patient records

Outcome

Validity (sensitivity, specificity, positive likelihood ratio) of the questionnaires compared to the reference standard (MPR)patient reported

The Morisky and MARS-5 questionnaires have poor sensitivity for measuring adherence to antihypertensive drugs in a primary care setting and cannot be recommended for this purpose.

Cite This Study

Steeg et al. (2009) conducted a cross-sectional in Hypertension (n=128). Morisky and MARS-5 questionnaires vs. Medication possession ratio (MPR) was evaluated on Validity (sensitivity, specificity, positive likelihood ratio) of adherence questionnaires compared to MPR. The Morisky and MARS-5 questionnaires demonstrated low sensitivity (31.9% and 8.5%, respectively) for measuring adherence to antihypertensive drugs compared to the medication possession ratio.

synapsesocial.com/papers/6aa57fe2fbd1e0d0baeeb4c9 https://doi.org/10.1111/j.1365-2753.2008.01038.x

Topics

Hypertension management

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Implication

Questionnaires' low sensitivity cautions against clinical reliance for adherence; leaves open need for validated tools versus objective measures in primary care.

Drug‐adherence questionnaires not valid for patients taking blood‐pressure‐lowering drugs in a primary health care setting

Discussion

Member takes

Implication

Study Design

Structured PICO

Cite This Study

Topics

Drug‐adherence questionnaires not valid for patients taking blood‐pressure‐lowering drugs in a primary health care setting

Discussion

Member takes

Implication

Study Design

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider