Key result
Neonatal acidosis in diabetic pregnancies is linked to prolonged bupivacaine half-life and greater placental transfer.
Why the study?
How does epidural anesthesia with bupivacaine affect acid-base status and bupivacaine pharmacokinetics in diabetic parturients and their infants?
Population
16 diabetic parturients and their infants undergoing cesarean section
Design
Cohort
Authors
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Neonatal acidosis may increase bupivacaine exposure in diabetic cesarean deliveries; hypothesis-generating for causality and pharmacokinetic effects.
Observational (n=16)
How does epidural anesthesia with bupivacaine affect acid-base status and bupivacaine pharmacokinetics in diabetic parturients and their infants?
In diabetic parturients undergoing cesarean section, neonatal acidosis is associated with maternal hypotension and alters the pharmacokinetics and placental transfer of bupivacaine.
Datta et al. (1981) conducted an observational in Diabetic parturients (n=16). Neonatal acidosis (umbilical artery pH <7.2) vs. Non-acidotic infants (umbilical artery pH >7.2) was evaluated on Placental transfer and half-life of bupivacaine. Neonatal acidosis in infants of diabetic parturients was associated with prolonged bupivacaine half-life and significantly greater placental transfer of bupivacaine.
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