Key result
Nonfatal reinfarction after thrombolysis for acute MI linked to ~78% higher 3-year mortality.
Why the study?
Does nonfatal reinfarction increase the risk of subsequent death in patients with acute myocardial infarction undergoing thrombolytic therapy?
Population
3,339 patients with acute myocardial infarction undergoing thrombolytic therapy entered into the…
Comparison
Nonfatal reinfarction (exposure) vs Matched control group without nonfatal…
Design
Cohort
Follow-up
3 years
Authors
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Nonfatal reinfarction after thrombolysis-treated AMI was associated with higher 3-year mortality; supports composite endpoint inclusion but leaves open causal confirmation.
Cohort (n=3,339)
Does nonfatal reinfarction increase the risk of subsequent death in patients with acute myocardial infarction undergoing thrombolytic therapy?
Absolute Event Rate: 14.1% vs 7.9%
p-value: p=<0.01
Nonfatal reinfarction is a strong and independent predictor of subsequent death in patients receiving thrombolytic therapy for acute myocardial infarction, validating its use in composite endpoints.
Mueller et al. (1995) conducted a cohort in Acute myocardial infarction (n=3,339). Nonfatal reinfarction vs. Matched control group without nonfatal reinfarction was evaluated on Cumulative 3-year death rate (p=<0.01). Nonfatal reinfarction following acute myocardial infarction treated with thrombolysis was associated with a significantly higher 3-year cumulative death rate (14.1% vs 7.9%, P<0.01).
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