Key result
Early goal-directed therapy trial evaluates reducing 30-day major complications after high-risk abdominal surgery.
Why the study?
Does early goal-directed therapy using arterial waveform analysis reduce major complications in patients scheduled for elective, high-risk abdominal surgery?
Population
542 patients scheduled for elective, high-risk abdominal surgery
Comparison
Early goal-directed therapy added to standard… vs Standard care with standard perioperative…
Design
RCT, randomization procedure stratified by center and type of surgery
Follow-up
30 days
Authors
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This RCT's results are needed before adopting arterial waveform-guided goal-directed therapy; leaves open current perioperative practice in high-risk abdominal surgery.
RCT (n=542)
Open-label
Stratified by center and type of surgery, block randomization with variable block size
Yes
Does early goal-directed therapy using arterial waveform analysis reduce major complications in patients scheduled for elective, high-risk abdominal surgery?
This study protocol describes a trial investigating whether early goal-directed therapy using arterial waveform analysis reduces major complications and mortality in patients undergoing high-risk abdominal surgery.
Montenij et al. (2014) conducted an RCT in High-risk abdominal surgery (n=542). Early goal-directed therapy using arterial waveform analysis vs. Standard care was evaluated on Combined endpoint of major complications in the first 30 days after the operation, including mortality. Early goal-directed therapy using arterial waveform analysis will be evaluated in a 542-patient randomized controlled trial to determine if it reduces 30-day major complications after high-risk abdominal surgery.
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