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February 1, 1975The Journal of Experimental MedicineOpen Access

Genetic linkage between serum levels of the third component of complement and the H-2 complex.

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Key result

Gene controlling serum C3 levels is linked to the H-2 complex in mice.

Authors

AFAna Maria da Costa FerreiraUniversidade de São PauloVNVictor NussenzweigNational Council for Scientific and Technological Development

Discussion

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Implication

Suggests MHC-linked C3 control in mice; leaves open whether analogous regulation affects human complement levels or immunity.

PICO

P
Population
Mice analyzed at 21 days of age to assess the genetic linkage between serum C3 levels and the H-2 complex.
E
Exposure / Comparator
H-2 complex genotype
O
Primary Outcome
Serum C3 levels

Cite This Study

Ferreira et al. (1975) studied this question. H-2 complex genotype was evaluated on Serum C3 levels. A gene controlling serum levels of the third component of complement (C3) is linked to the H-2 complex in mice.

synapsesocial.com/papers/6aa59ac2c616a76b5feecaf1https://doi.org/10.1084/jem.141.2.513
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1COMPLEMENT-DEPENDENT RELEASE OF IMMUNE COMPLEXES FROM THE LYMPHOCYTE MEMBRANE1973 · 75 citations
  2. 2A GENE LOCUS CONCERNED WITH HEMOLYTIC COMPLEMENT IN MUS MUSCULUS1963 · 65 citations
  3. 3A Single Gene Controlling Hemolytic Complement and a Serum Antigen in the Mouse1964 · 72 citations
  4. 4DEFICIENCY OF THE FIFTH COMPONENT OF COMPLEMENT IN MICE WITH AN INHERITED COMPLEMENT DEFECT1967 · 281 citations
  5. 5EVIDENCE FOR LINKAGE BETWEEN HL-A HISTOCOMPATIBILITY GENES AND THOSE INVOLVED IN THE SYNTHESIS OF THE SECOND COMPONENT OF COMPLEMENT1974 · 260 citations