Histocompatibility-Linked Genetic Control of Disease Susceptibility
Population
Mice (SWR/J, C3H/HeJ, F1 hybrids, F2 backcrosses, and congenic H-2(q/q) and H-2(k/k) strains)
Comparison
Intracerebral injection of LCM virus vs Different genetic backgrounds (H-2, H-2, and H-2)
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Does not inform human LCM management; leaves open MHC gene roles in viral susceptibility pending translational studies.
Structured PICO
P
Population
Mice (SWR/J, C3H/HeJ, F1 hybrids, F2 backcrosses, and congenic H-2(q/q) and H-2(k/k) strains)
I
Intervention
Intracerebral injection of LCM virus
C
Comparator
Different genetic backgrounds (H-2(q/q), H-2(k/k), and H-2(q/k))
O
Outcome
Susceptibility to acute necrotizing inflammatory disease
Demonstrates that susceptibility to LCM virus-induced acute necrotizing inflammatory disease is genetically controlled and linked to the H-2 locus in mice.
Cite This Study
Oldstone et al. (1973) studied this question.