Increased waist circumference in overweight and obese subjects was significantly and independently associated with decreased total adiponectin levels.
Observational (n=206)
Open-label
No
Does individualized structured dietary education and subsequent visceral fat loss improve total adiponectin levels in overweight and obese subjects?
In overweight and obese subjects, visceral fat loss achieved through dietary education significantly reduces inflammatory markers but does not significantly increase total adiponectin levels.
Effect estimate: Standardized Regression coefficient -0.256 (95% CI -0.115 to -0.008)
p-value: p=0.024
BACKGROUND: Visceral obesity and related diabetes is reaching epidemic proportions in the United Arab Emirates (UAE). Adiponectin is a hormone that is secreted by adipose tissue and may play an important role in obesity-related morbidity. The aim of this study was to investigate total adiponectin levels in overweight and obese UAE subjects visiting health care facilities for weight management. METHODS: All overweight and obese subjects visiting community health centers were invited to take part in the study. Two hundred and six participants received individualized structured dietary education for weight management. Demographic data, anthropometric measurements and fasting venous blood samples were taken for measurements of total adiponectin and markers of inflammation and nutritional status at baseline and follow up. Multivariate analysis was performed to determine the independent effects of prognostic factors on serum adiponectin levels. RESULTS: A total of 193 (93%) females with a mean age (±SD) 36 ± 11 years were included in the analysis. During a follow up period of 427 ± 223 days, participants received 13 ± 5 structured dietary education sessions. We observed decreased levels of total adiponectin with increasing quartiles of both waist circumference (WC) and body mass index (BMI). Male gender and history of both gestational and type 2 diabetes were associated with significantly lower total adiponectin levels (p < 0.05). After adjusting for age, gender, BMI and hip circumference, multiple regression analysis revealed a significant and independent association between waist circumference and total adiponectin levels. At follow up visceral fat loss was associated with a significant decrease in inflammatory markers and a non-significant increase in total adiponectin levels. CONCLUSION: Increased visceral fat in overweight and obese subjects is associated with decreased total adiponectin levels. The health benefits of increasing adiponectin levels using different dietary intervention strategies need to be explored in larger studies. TRIAL REGISTRATION: NCT01691365 , registered on 11/09/2012.
Gariballa et al. (2019) conducted an observational in Overweight and obesity (n=206). Structured dietary education for weight management vs. Baseline was evaluated on Association between waist circumference and total adiponectin levels (Standardized Regression coefficient -0.256, 95% CI -0.115 to -0.008, p=0.024). Increased waist circumference in overweight and obese subjects was significantly and independently associated with decreased total adiponectin levels.
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