Key result
Short, intense exercise does not affect D-dimer levels in sailors at low thromboembolic risk.
Why the study?
Does short, intense exercise affect D-dimer levels in low-risk sailors?
Observational (n=42)
Does short, intense exercise affect D-dimer levels in low-risk sailors?
Short, intense exercise does not affect D-dimer levels, suggesting recent exertion does not confound its use as a screening tool for venous thromboembolism.
Answers are grounded in this paper and cite their sources.
May not confound D-dimer screening after intense exercise in low-risk groups; leaves open extension to higher-risk populations.
OBJECTIVE: Many health care providers encounter patients with complaints of calf pain, swelling, chest pain, shortness of breath, and syncope after intense exercise. Unfortunately, these symptoms alone or in constellation could represent an underlying venous thromboembolism. A negative D-dimer can often exclude moderate-risk patients. We examined the change in D-dimer levels following strenuous exercise. METHODS: In a prospective study of 42 sailors, D-dimer levels were drawn before and after a workout that simulated the standardized Navy Physical Readiness Test. Data were analyzed using the Kruskal-Wallis and Kolmogorov-Smirnov tests. RESULTS: No significant change was found between pre- and postexercise levels. CONCLUSION: Findings indicate that neither level of conditioning, nor short, intense exercise affected D-dimer levels in participants who were considered extremely at low risk for thromboembolic disease. In essence, this allowed us to test the test, and therefore adds to our understanding of a screening tool used in the pursuit of a disease with significant consequence.
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Koehler et al. (2014) conducted an observational in Healthy (low risk for thromboembolic disease) (n=42). Strenuous exercise vs. Pre-exercise baseline was evaluated on Change in D-dimer levels. Short, intense exercise did not significantly affect D-dimer levels in sailors at extremely low risk for thromboembolic disease.
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