Key result
Modified constant infusion method overestimates standard inulin clearance by ~4.5 ml/min/1.73 m2, proving unsuitable.
Why the study?
Does the steady-state constant infusion method accurately measure inulin and PAH clearance compared to the standard bladder clearance method in patients with renal disease?
Population
25 patients with renal disease
Comparison
Steady-state constant infusion method and… vs Standard method of bladder clearance (StM)
Design
Cross-sectional
Follow-up
27 hours
Authors
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Clinicians should avoid modified constant infusion for precise GFR measurement in renal disease; cross-sectional data leaves open validation of alternatives.
Observational (n=25)
Does the steady-state constant infusion method accurately measure inulin and PAH clearance compared to the standard bladder clearance method in patients with renal disease?
Mean Difference: 4.5
p-value: p=<0.001
The steady-state constant infusion method is not suitable for accurate measurement of inulin and PAH clearance in patients with renal disease due to incomplete urinary recovery and circadian rhythms.
Acker et al. (1995) conducted an observational in renal disease (n=25). Modified constant infusion method (ModCIM) vs. Standard method of bladder clearance (StM) was evaluated on Inulin clearance (MD 4.5 ml.min-1 x 1.73 m-2, p=<0.001). The modified constant infusion method overestimated standard bladder clearance of inulin by a mean of 4.5 ml/min/1.73 m2 (P<0.001), indicating it is unsuitable for accurate measurement.
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