Why the study?
How do the total body and renal clearances of inulin measured by a single intravenous injection compare to the constant infusion method in healthy volunteers and patients with chronic renal failure?
Population
37 healthy adult volunteers and 10 patients with stable chronic renal failure (n=47)
Comparison
Single intravenous injection of inulin vs Standard constant infusion method of inulin
Design
Other
Follow-up
up to 8 hours
Authors
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Caution advised for single-bolus inulin GFR estimates; leaves open optimal sampling protocols for research and practice.
How do the total body and renal clearances of inulin measured by a single intravenous injection compare to the constant infusion method in healthy volunteers and patients with chronic renal failure?
The elimination of inulin after a single intravenous injection is highly concentration-dependent, and clearance estimates depend critically on sampling and pharmacokinetic modeling choices.
Prescott et al. (1991) studied this question.
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