Key result
Simultaneous IV inulin and 15N2-urea yields distinct distribution volumes and compartmental flows matching cardiac output.
Population
5 normal subjects
Design
Other
Authors
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Should not yet guide clinical estimates of cardiac output or drug distribution; leaves open validation of tracer kinetics for compartmental modeling.
Simultaneous analysis of inulin and urea kinetics can be used to model drug distribution and accurately estimate compartmental blood flows and cardiac output.
Odeh et al. (1993) studied Healthy volunteers (n=5). Simultaneous intravenous injection of inulin and 15N2-urea was evaluated on Distribution volumes and compartmental blood flows. Simultaneous intravenous injection of inulin and 15N2-urea yielded mean distribution volumes of 0.164 L/kg and 0.670 L/kg respectively, with compartmental blood flows matching cardiac output.
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