What is the clinical evidence from this study?

Study design: Case Report. Population: Foot-and-mouth disease virus (FMDV) associated myocarditis (n=2). Intervention: Foot-and-mouth disease virus (FMDV) infection vs. Uninfected control.

What does this research mean for the field?

Fatal myocarditis in pigs acutely infected with foot-and-mouth disease virus is characterized by cardiomyocyte degeneration and a mononuclear inflammatory infiltrate predominantly composed of monocyte-lineage cells and putative CD8+ natural killer cells. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

July 11, 2014Acta veterinaria ScandinavicaOpen Access

Morphologic and phenotypic characteristics of myocarditis in two pigs infected by foot-and mouth disease virus strains of serotypes O or A

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Key result

Fatal FMDV myocarditis features cardiomyocyte degeneration and a distinct CD8+ mononuclear inflammatory infiltrate.

Authors

CSCarolina StenfeldtKansas State University JPJuan M. PachecoSaint Joseph's University MBManuel V. BorcaNational Agricultural Statistics Service

Discussion

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Implication

Hypothesis-generating for CD8+ subsets in viral myocarditis; leaves open relevance to other species or models.

Study Design

Type

Case Report (n=2)

PICO

Population

Two castrated male Yorkshire pigs (approximately 20 kg) that died of acute myocarditis 3 to 5 days after experimental infection with foot-and-mouth disease virus.

Exposure / Comparator

Foot-and-mouth disease virus (FMDV) infection vs Uninfected control

Limitations

Descriptive analysis based on only two cases
Differences in exposure methods and viral strains between the two cases
Inability to determine the causality of the variation in cellular responses

Cite This Study

Stenfeldt et al. (2014) conducted a case report in Foot-and-mouth disease virus (FMDV) associated myocarditis (n=2). Foot-and-mouth disease virus (FMDV) infection vs. Uninfected control was evaluated. Fatal myocarditis in two pigs infected with FMDV was characterized by cardiomyocyte degeneration and a mononuclear inflammatory infiltrate containing a distinct subset of CD8+ cells.

synapsesocial.com/papers/6aa5b6a1affc7bfe5364b470 https://doi.org/10.1186/s13028-014-0042-6

Topics

Myocarditis

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Morphologic and phenotypic characteristics of myocarditis in two pigs infected by foot-and mouth disease virus strains of serotypes O or A

Discussion

Member takes

Implication

Study Design

PICO

Limitations

Cite This Study

Topics

Morphologic and phenotypic characteristics of myocarditis in two pigs infected by foot-and mouth disease virus strains of serotypes O or A

Discussion

Member takes

Implication

Study Design

PICO

Limitations

Cite This Study

Also Consider

Topics

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