Body weight changes in patients with type 2 diabetes and a recent acute coronary syndrome: an analysis from the EXAMINE trial
View Full Paper
Ask AI
Bookmark
Share
Key result
Post-ACS weight loss ≥5% in T2D is linked to ~79% higher all-cause mortality.
- HR 1.79
- 95% CI 1.33-2.42
- P<0.001
- n=5,380
Why the study?
Patients with type 2 diabetes frequently experience weight changes over time, but the prognostic impact of these weight gains or losses required further study.
Does a change in body weight (loss or gain ≥ 5%) affect the risk of subsequent adverse outcomes in patients with type 2 diabetes and a recent acute coronary syndrome?
Population
5380 patients with T2D and a recent acute coronary syndrome
Comparison
Weight loss ≥ 5% vs stable weight vs weight gain ≥ 5%
Design
Post-hoc analysis of a randomized controlled trial
Follow-up
Median 1.6 (1.0-2.1) years
Authors
Discussion
Loading...
Member takes
Implication
≥5% weight loss may signal higher mortality risk post-ACS in T2D; hypothesis-generating and should not yet change practice.
Study Design
Type
Cohort (n=5,380)
Multicenter
Yes
Structured PICO
Does a change in body weight (loss or gain ≥ 5%) affect the risk of subsequent adverse outcomes in patients with type 2 diabetes and a recent acute coronary syndrome?
P
Population
5,380 patients with type 2 diabetes and a recent acute coronary syndrome, followed for a median of 1.6 years to evaluate the association between body weight changes and cardiovascular outcomes.
E
Exposure
Weight loss ≥ 5% or weight gain ≥ 5% of baseline weight
C
Comparator
Stable weight (change < 5%)
O
Outcome
All-cause mortalityhard clinical
Main Result
Hazard Ratio: 1.79 (95% CI 1.33–2.42)
p-value: p=<0.001
In patients with type 2 diabetes and a recent acute coronary syndrome, a ≥ 5% loss of body weight is associated with a higher risk of subsequent cardiovascular events and mortality.
Limitations
- Could not distinguish intentional from unintentional weight loss
- Observational findings prone to confounding, meaning causality cannot be established
- Some cancer diagnoses might have passed unnoticed, potentially contributing to mortality
- Findings may not be applicable to contemporary cohorts treated with SGLT2 inhibitors and GLP1 receptor agonists
- Echocardiography was not performed, limiting insight into the underlying causes of weight gain
- Relatively short median follow-up of 1.6 years
Cite This Study
Ferreira et al. (2021) conducted a cohort in Type 2 diabetes and recent acute coronary syndrome (n=5,380). Weight loss ≥ 5% of baseline weight vs. Stable weight was evaluated on All-cause mortality (HR 1.79, 95% CI 1.33-2.42, p=<0.001). In patients with type 2 diabetes and a recent acute coronary syndrome, a body weight loss of ≥5% was associated with a 79% higher risk of all-cause mortality (HR 1.79).
View Full Paper
Ask AI
Bookmark
Share