Key result
End stage renal failure was associated with significantly prolonged maximum atrial electromechanical coupling time compared to healthy controls (61 vs 47 ms; P<0.001).
Why the study?
Does end-stage renal failure affect atrial electromechanical coupling times in normotensive, nondiabetic patients?
Case-Control (n=88)
Does end-stage renal failure affect atrial electromechanical coupling times in normotensive, nondiabetic patients?
Absolute Event Rate: 61% vs 47%
p-value: p=<0.001
Atrial electromechanical coupling times are significantly prolonged in normotensive, nondiabetic patients with end-stage renal failure, suggesting an intrinsic effect of ESRF on atrial conduction.
Prolonged atrial electromechanical coupling in ESRF may signal conduction changes; leaves open arrhythmia prediction or intervention needs.
BACKGROUND: There are no definite data about the atrial electromechanical coupling times (AEMCT) in patients with end stage renal failure (ESRF). The aim of this study was to investigate the AEMCT in ESRF patients without hypertension (HT) and diabetes mellitus. METHODS: The study population consisted of 47 normotensive, nondiabetic ESRF patients and 41 healthy age/gender-matched control subjects. The time intervals from the onset of P-wave on the surface electrocardiogram to the beginning of late diastolic A-wave (PA) were obtained from the lateral mitral annulus (PA-lateral, maximum AEMCT), septal annulus (PA-septal), and tricuspid lateral annulus (PA-tricuspid). Time intervals were corrected according to the heart rate. The difference between PA-septal and PA-tricuspid (right AEMCT), PA-lateral and PA-septal (left AEMCT), and PA-lateral and PA-tricuspid (inter AEMCT) were calculated. Corrected time intervals were used for calculations. RESULTS: Groups were similar for age (52 ± 12.3 vs. 49.9 ± 6 years, P > 0.05) and gender. Maximum (61 ± 20 vs. 47 ± 13 ms; P < 0.001) AEMCT was significantly higher in the patients compared with the control group, but septal and tricuspid EMCT were not different (P > 0.05). Both inter-atrial (37 ± 21 vs. 24 ± 16 ms, P = 0.002) and left atrial (25 ± 18 vs. 12 ± 9 ms; P < 0.001) EMCT were significantly higher in patients when compared with the controls but intra-right atrial EMCT was not different. CONCLUSIONS: Atrial conduction parameters such as maximal EMCT, left atrial, and inter-atrial EMCTs were prolonged in ESRF patients. This prolongation is seen in ESRF patients even in the absence of factors that affect atrial coupling, such as HT.
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Karavelioğlu et al. (2013) conducted a case-control in End stage renal failure (ESRF) (n=88). End stage renal failure vs. Healthy controls was evaluated on Maximum atrial electromechanical coupling time (AEMCT) (p=<0.001). End stage renal failure was associated with significantly prolonged maximum atrial electromechanical coupling time compared to healthy controls (61 vs 47 ms; P<0.001).
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