Key result
Soft-tissue sarcoma linked to ~10% incidence of predominantly osteolytic skeletal metastases.
Cohort (n=277)
Skeletal metastases occur in approximately 10% of patients with soft-tissue sarcoma, often presenting as osteolytic lesions in axial or regional bones.
May support skeletal surveillance in soft-tissue sarcoma; leaves open optimal protocols and outcome impact.
We reviewed 277 patients with soft-tissue sarcoma (STS) treated between 1975 and 1995 to study the incidence, distribution, time of appearance, and radiological findings of skeletal metastases. Of these, 28 (10.1%) had metastases within a mean period of 18.6 months after admission. The incidence of skeletal metastases differed among the histological subtypes of sarcoma; alveolar soft-part sarcoma, dedifferentiated liposarcoma, angiosarcoma, and rhabdomyosarcoma tended to show higher incidences. The regional bones close to the primary tumour were affected in 13 (46.4%) of the 28 patients, and the axial bones in 18 (64.3%). Radiologically, the metastatic bony lesions predominantly showed osteolytic changes, and there were pathological fractures in 21 of 44 lesions.
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Yoshikawa et al. (1997) conducted a cohort in soft-tissue sarcoma (STS) (n=277). Soft-tissue sarcoma was evaluated on incidence of skeletal metastases. Soft-tissue sarcoma was associated with a 10.1% incidence of skeletal metastases within a mean of 18.6 months, predominantly affecting regional and axial bones with osteolytic changes.
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