Key result
Glycine-ethanol irrigating fluids reduce heart rate and cardiac output and elevate MAP versus mannitol or sorbitol.
Why the study?
Do moderate amounts of different irrigating fluids induce cardiac stress when infused intravenously into healthy volunteers?
Population
10 healthy male volunteers
Comparison
Intravenous infusion of 15 mL/kg of glycine… vs Intravenous infusion of 15 mL/kg of 3% mannitol…
Design
Other
Follow-up
30 minutes after infusion
Authors
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Glycine-ethanol irrigants may induce cardiac stress during procedures; leaves open comparative outcomes versus mannitol or sorbitol.
Do moderate amounts of different irrigating fluids induce cardiac stress when infused intravenously into healthy volunteers?
Irrigating fluids containing glycine and ethanol have specific haemodynamic effects, including increased systemic resistance and reduced cardiac output, which do not occur with mannitol or sorbitol solutions.
Nilsson et al. (1996) studied Healthy volunteers (n=10). Glycine (1% or 1.5%) containing 1% ethanol vs. 3% mannitol (with 1% ethanol) or sorbitol 2%-mannitol 1% (no ethanol) was evaluated on Central haemodynamic responses (heart rate, cardiac output, mean arterial pressure). Irrigating fluids containing glycine and ethanol reduced heart rate and cardiac output and elevated mean arterial pressure, an effect not seen with mannitol or sorbitol solutions.
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