Key result
SLC8A1 polymorphism rs9789739 is linked to ~12% higher LVH risk but lower HTN risk.
Why the study?
SLC8A1 polymorphisms have been linked to salt-sensitive hypertension, but their association with HTN and LVH in the Korean population required evaluation.
Are genetic polymorphisms of SLC8A1 associated with the development of hypertension and left ventricular hypertrophy in the Korean population?
Case-Control (n=8,840)
Are genetic polymorphisms of SLC8A1 associated with the development of hypertension and left ventricular hypertrophy in the Korean population?
Odds Ratio: 1.12 (95% CI 1.01–1.24)
p-value: p=3.77×10^-2
Polymorphisms of the SLC8A1 gene, particularly rs1002671 and rs9789739, are significantly associated with hypertension and left ventricular hypertrophy in the Korean population.
Should not alter hypertension or LVH management; extends observational genetic associations in Koreans but requires prospective validation.
Hypertension (HTN) is one of the major chronic diseases, and HTN is defined as being in a state of continuous high blood pressure.Left ventricular hypertrophy (LVH) is a condition in which the mass of the left ventricle has increased, and HTN is a leading cause of LVH.HTN and LVH are known to be caused by the interaction of environmental factors and genetic factors.It has been reported that the polymorphisms of SLC8A1, among the genetic factors that affect high blood pressure, are related to salt sensitivity hypertension.In this study, the genetic polymorphisms of SLC8A1 were chosen based on the Korean Genome and Epidemiology data.Logistic regression analysis was then performed for HTN and LVH.Linear regression analysis was also performed for systolic blood pressure (SBP) and diastolic blood pressure (DBP).As a result, 5 SNPs showed statistically significant associations (P＜0.05) with HTN, and 10 SNPs showed statistically significant associations with LVH.rs1002671 and rs9789739 showed significant correlation at the same time with HTN and LVH.These results suggest that the polymorphisms of the SLC8A1 gene are linked to the development of HTN and LVH in Koreans.We expect these results to help us understand the pathogenic mechanisms for HTN and LVH.
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Park et al. (2019) conducted a case-control in Hypertension and Left Ventricular Hypertrophy (n=8,840). SLC8A1 genetic polymorphisms (rs9789739) vs. Major allele carriers was evaluated on Left ventricular hypertrophy (LVH) (OR 1.12, 95% CI 1.01-1.24, p=3.77×10^-2). The SLC8A1 genetic polymorphism rs9789739 was significantly associated with an increased risk of left ventricular hypertrophy (OR 1.12) and a decreased risk of hypertension in the Korean population.
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