Key result
Angiogenin triggers NOS activity in endothelial cells independently of its RNase activity.
Angiogenin triggers nitric oxide synthase activity in endothelial cells independently of its RNase activity.
Should not yet influence care; leaves open RNase-independent angiogenin pathways for vascular research.
Nitric oxide (NO), a biological mediator involved in vascular physiology, was sensed electrochemically using a microelectrode array. Angiogenin was shown to trigger nitric oxide synthase (NOS) activity in human umbilical vein endothelial cells and embryonic stem cell derived endothelial cells independently from its RNase activity.
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Trouillon et al. (2011) studied this question. Angiogenin triggers nitric oxide synthase activity in human umbilical vein and embryonic stem cell-derived endothelial cells independently from its RNase activity.
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