Key result
ACE I/D polymorphism lacks association with first-episode schizophrenia but D/D genotype links to higher negative symptoms.
Why the study?
Is the ACE gene I/D polymorphism associated with susceptibility to or symptom severity of first-episode schizophrenia in a Chinese Han population?
Case-Control (n=758)
Is the ACE gene I/D polymorphism associated with susceptibility to or symptom severity of first-episode schizophrenia in a Chinese Han population?
p-value: p=>0.05
While the ACE gene I/D polymorphism is not associated with susceptibility to first-episode schizophrenia, the D/D genotype may be linked to more severe negative symptoms in a Chinese Han population.
Should not guide genetic risk assessment in schizophrenia; leaves open D/D genotype link to negative symptom severity for replication.
BACKGROUND: Angiotensin-converting enzyme (ACE), a key enzyme of the renin-angiotensin system, can modulate dopamine turnover in the midbrain. Previous studies have revealed an association between ACE gene insertion/deletion (I/D) polymorphism and chronic schizophrenia, yet results are conflicting. OBJECTIVE: The primary objective of this study was to examine whether the ACE gene I/D polymorphism is associated with first-episode patients with schizophrenia (FEP) in a Chinese Han population. METHODS: The presence of the polymorphism was determined in 220 FEP and 538 healthy controls using a case-control design. We assessed the psychopathology in 212 FEP using the Positive and Negative Syndrome Scale (PANSS). RESULTS: The allelic and genotypic frequencies of the ACE gene I/D polymorphism did not significantly differ between FEP and healthy controls (both p>0.05). However, the negative PANSS symptom was significantly higher in FEP with the D/D genotype than those with I/D and I/I genotypes (all p<0.05) even after Bonferroni corrections (all p<0.05). Furthermore, the D allele of the ACE gene was associated with higher negative PANSS symptom score in FEP. CONCLUSIONS: Our results indicated that even though the ACE gene I/D polymorphism did not associate with FEP, it may play a role in susceptibility to the negative PANSS symptom of FEP in a Chinese Han population.
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Hui et al. (2014) conducted a case-control in First-episode schizophrenia (n=758). ACE gene insertion/deletion (I/D) polymorphism vs. Healthy controls was evaluated on Allelic and genotypic frequencies of the ACE gene I/D polymorphism (p=>0.05). The ACE gene I/D polymorphism was not significantly associated with first-episode schizophrenia (p>0.05), but the D/D genotype was linked to higher negative symptom scores (p<0.05).
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