Key result
Intensive multifactor risk reduction cuts new coronary lesion formation ~38% versus usual care.
Why the study?
Does an intensive multifactor risk reduction program reduce the rate of development of new coronary artery lesions in patients with coronary artery disease?
Population
300 men and women with coronary artery disease
Comparison
Intensive multifactor risk reduction program… vs Usual care
Design
RCT, Randomized
Follow-up
4 years
Authors
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Supports intensive multifactor risk reduction in CAD patients; extends prior angiographic trials on lesion prevention.
RCT (n=300)
randomized
Does an intensive multifactor risk reduction program reduce the rate of development of new coronary artery lesions in patients with coronary artery disease?
Absolute Event Rate: 4.7% vs 7.6%
p-value: p=0.05
An intensive multifactor risk reduction program over 4 years tends to diminish the angiographic development of new coronary atherosclerotic lesions in patients with coronary artery disease.
Quinn et al. (1994) conducted an RCT in coronary artery disease (n=300). Intensive multifactor risk reduction program vs. Usual care was evaluated on New coronary lesion formation per segment (p=0.05). An intensive multifactor risk reduction program over 4 years reduced new coronary lesion formation per segment compared to usual care (4.7% vs 7.6%; p=0.05).
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