Key result
AGT g.5855G>A polymorphism linked to protection against essential hypertension.
Why the study?
Are tagged SNPs in the AGT gene associated with susceptibility to essential hypertension in an Indian population?
Population
424 individuals from an Indian population, comprising 202 patients with essential hypertension and 222…
Comparison
Presence of five tagged SNPs in the AGT gene vs Absence of the specific SNPs / normotensive…
Design
Case-control
Authors
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Supports AGT locus in Indian hypertension susceptibility; hypothesis-generating and requires independent replication before any clinical consideration.
Case-Control (n=424)
Are tagged SNPs in the AGT gene associated with susceptibility to essential hypertension in an Indian population?
The g.5855G>A polymorphism in the AGT gene may confer a protective effect against the development of essential hypertension in the Indian population.
Gunda et al. (2016) conducted a case-control in Essential hypertension (n=424). AGT gene tagged SNPs (specifically g.5855G>A) vs. Normotensives was evaluated on Development of essential hypertension. The g.5855G>A polymorphism in the AGT gene conferred significant protection against the development of essential hypertension in an Indian population.
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