Key result
Polymorphisms g.6635G > A, g.6506G > A, and g.13828T > C were significantly associated with increased risk of essential hypertension, while haplotype GGGC had a protective effect (p=0.0059).
Why the study?
Are tagged SNPs of the AGT gene associated with susceptibility to essential hypertension in an Indian population?
Population
445 individuals from India, comprising 215 with essential hypertension and 230 normotensives.
Comparison
Genotyping for four tagged SNPs at the AGT locus vs Normotensive controls
Design
Case-control
Authors
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AGT variants may aid hypertension risk stratification in Indians; leaves open validation and clinical utility in prospective studies.
Case-Control (n=445)
Are tagged SNPs of the AGT gene associated with susceptibility to essential hypertension in an Indian population?
p-value: p=0.0059
Specific tagged SNPs and haplotypes of the AGT gene are associated with susceptibility to essential hypertension in the Indian population.
Swapna et al. (2014) conducted a case-control in Essential hypertension (n=445). AGT gene tagged SNPs (g.6635G > A, g.6506G > A, g.12840G > A, g.13828T > C) vs. Normotensives / Wild-type genotypes was evaluated on Susceptibility to essential hypertension (p=0.0059). Polymorphisms g.6635G > A, g.6506G > A, and g.13828T > C were significantly associated with increased risk of essential hypertension, while haplotype GGGC had a protective effect (p=0.0059).
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