Key result
The AGT g.15241A>G polymorphism is linked to ~108% greater essential hypertension risk in males.
Why the study?
The association of g.15241A>G polymorphism in intron 3 of the AGT gene with essential hypertension had not been previously reported.
Does the g.15241A>G polymorphism in the AGT gene increase the risk of essential hypertension?
Population
180 hypertensive and 188 normotensive subjects
Comparison
Presence of G allele vs absence of G allele in intron 3 of AGT gene
Design
Case-control study
Authors
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Suggests male-specific AGT risk for hypertension; hypothesis-generating and requires independent validation.
Case-Control (n=368)
Does the g.15241A>G polymorphism in the AGT gene increase the risk of essential hypertension?
Odds Ratio: 2.08 (95% CI 1.02–4.21)
p-value: p=0.04
The g.15241A>G polymorphism in the AGT gene is associated with a twofold increased risk of essential hypertension in males.
Gunda et al. (2012) conducted a case-control in Essential Hypertension (n=368). g.15241A>G polymorphism in intron 3 of AGT gene (G allele) vs. Non-carriers / normotensive subjects was evaluated on Essential hypertension in males (OR 2.08, 95% CI 1.02-4.21, p=0.04). The g.15241A>G polymorphism in the AGT gene conferred a high risk for essential hypertension in males carrying the G allele (OR 2.08; 95% CI 1.02-4.21; P=0.04).
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