Key result
8-week very low calorie diet linked to improved LV MPI and ~23% less epicardial fat.
Why the study?
Does a very low calorie diet improve cardiac function and reduce epicardial fat in obese patients without heart disease?
Cohort (n=52)
Open-label
No
Does a very low calorie diet improve cardiac function and reduce epicardial fat in obese patients without heart disease?
Absolute Event Rate: 0.37% vs 0.42%
p-value: p=<0.0001
An 8-week very low calorie diet significantly improves biventricular systolic and diastolic function and reduces epicardial fat in obese patients without heart disease.
Short-term VLCD effects on cardiac structure in severe obesity remain hypothesis-generating; randomized trials needed before any practice consideration.
Objective: The objective of the study was to evaluate the effect of an eight week period of very low calorie diet (VLCD) on heart function and amount of epicardial adipose tissue in obese people without heart disease.Methods: Fifty-two obese patients (38 women, 14 men, mean age 47.6±12.3years,mean BMI 46.2±7.0kg/m 2 ) were assigned to a VLCD enriched with vegetables for eight weeks.Transthoracic echocardiography was performed before and after the diet period.Left ventricular size, ejection fraction, diastolic function, left and right ventricular myocardial performance index (MPI) and thickness of epicardial adipose tissue were measured.Heart rate, blood pressure and plasma glucose and triglyceride concentration were also analysed.Results: During the diet period the BMI decreased from 46.2±7.0kg/m 2 to 41.8±6.1kg/m 2 (p<0.0001).The left ventricular MPI decreased from 0.42±0.07 to 0.37±0.07(p<0.0001) and right ventricular MPI decreased from 0.30±0.09to 0.27±0.09(p=0.0256)showing significant systolic and diastolic improvement in the performance of both ventricles.The thickness of epicardial fat decreased from 4.4±1.5mm to 3.4±1.4mm(p<0.0001).The heart rate decreased from 75.8±9.7beats/minto 67.0±10.3beats/min (p<0.0001) and the systolic blood pressure decreased from 140±14.3mmHg to 135.2±10.6mmHg(p=0.0087).The plasma glucose concentration decreased from 6.71±1.96mmol/l to 6.02±1.59mmol/l(p<0.0001).The plasma triglyceride concentration decreased from 1.77±0.89mmol/lto 1.36±0.68mmol/l(p=0.0002).Conclusion: VLCD caused during only eight weeks period significant reduction in BMI as well as in the amount of epicardial fat and significant improvement in the systolic and diastolic function of both ventricles in obese persons.
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Heidi Luotolahti (2016) conducted a cohort in Obesity (n=52). Very low calorie diet (VLCD) vs. Baseline (before diet) was evaluated on Left ventricular myocardial performance index (MPI) (p=<0.0001). An 8-week very low calorie diet significantly improved left ventricular myocardial performance index from 0.42 to 0.37 and reduced epicardial fat thickness from 4.4 mm to 3.4 mm in obese patients.
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