Key result
Moderate exercise prevents a ~16 mmHg rise in sitting systolic BP among AGT M homozygotes.
Why the study?
Does moderate intensity exercise improve blood pressure in middle-aged men based on the angiotensinogen M235T polymorphism?
Population
140 middle-aged men
Comparison
Moderate intensity exercise vs Reference group
Design
RCT, randomized
Follow-up
6 years
Authors
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Genotype-informed exercise counseling may optimize BP control in middle-aged men; extends AGT polymorphism associations with long-term RCT evidence.
RCT (n=140)
randomized
Does moderate intensity exercise improve blood pressure in middle-aged men based on the angiotensinogen M235T polymorphism?
Absolute Event Rate: -1% vs 14.6%
p-value: p=0.007
Regular moderate intensity exercise attenuates aging-related increases in systolic BP and decreases diastolic BP specifically among M homozygotes of the AGT gene M235T polymorphism.
Rauramaa et al. (2002) reported an RCT. Moderate intensity exercise vs. Reference group was evaluated on Sitting systolic blood pressure change in M homozygotes (p=0.007). Moderate intensity exercise over 6 years attenuated sitting systolic BP increases (-1.0 vs +14.6 mmHg, P=0.007) in middle-aged men who are M homozygotes of the AGT gene M235T polymorphism.
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