Key result
Intramyocardial electrograms achieve 100% sensitivity for detecting moderate cardiac allograft rejection in a canine model.
Why the study?
Does intramyocardial electrogram recording accurately detect cardiac allograft rejection compared to histology in a canine model?
Population
Ten beagle dogs with heterotopic neck hearts on cyclosporin A immunosuppression.
Comparison
Intramyocardial electrogram recordings via three… vs Serial myocardial biopsies and autopsy histology.
Design
Preclinical
Authors
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Does not support clinical adoption in transplant patients; leaves open validation of intramyocardial electrograms for human rejection surveillance.
Does intramyocardial electrogram recording accurately detect cardiac allograft rejection compared to histology in a canine model?
Recording multiple, preferably bipolar, intramyocardial electrogram leads enhances the diagnostic reliability of detecting moderate cardiac allograft rejection.
Grauhan et al. (1993) studied Cardiac allograft rejection (n=10). Intramyocardial electrogram recordings (IMEG) vs. Serial myocardial biopsies was evaluated on Sensitivity for detecting allograft rejection. Intramyocardial electrogram recordings using a combination of unipolar and bipolar leads achieved 100% sensitivity for detecting moderate cardiac allograft rejection in a canine model.
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