Key result
Norovirus GII accounts for ~97% of pediatric acute diarrhea cases, frequently presenting as severe.
Why the study?
The study was conducted to investigate the correlation between norovirus genogroup and the severity of acute diarrhea in pediatric patients.
Is there a correlation between norovirus genogroup and the severity of acute diarrhea in pediatric patients?
Cross-Sectional (n=31)
No
Is there a correlation between norovirus genogroup and the severity of acute diarrhea in pediatric patients?
Norovirus GII is the most prevalent cause of norovirus-associated acute diarrhea in this Indonesian pediatric cohort, frequently manifesting as moderate to severe diarrhea.
Norovirus GII predominance with 30% severe cases supports local surveillance; cross-sectional data leaves open genogroup-severity correlation.
Background: The objective of this study was to investigate the correlation between norovirus genogroup and severity of acute diarrhea in pediatric patients at the Dr. Soetomo Hospital, Surabaya, Indonesia. Methods: This cross-sectional study involved 31 participants aged 1-60 months admitted to the hospital with acute diarrhea from April 2012 to March 2013. Norovirus genogroups (GI and II) were identified from patient stool using reverse transcription polymerase chain reaction (RT-PCR). Severity was measured using the Ruuska and Vesikari scoring system. Results: In total, 91 stool samples were obtained, of which 31 (19%) were norovirus positive. Norovirus GI was found in one sample with mild diarrhea. Norovirus GII was found in 30 samples (96.8%); one sample with mild diarrhea (3.3%), 20 samples with moderate diarrhea (66.7%), and nine samples with severe diarrhea (30%). Conclusion: Norovirus GII was the most prevalent cause of acute diarrhea and 30% of the cases manifested as severe diarrhea.
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Athiyyah et al. (2020) conducted a cross-sectional in acute diarrhea (n=31). Norovirus genogroup was evaluated on Severity of acute diarrhea measured using the Ruuska and Vesikari scoring system. Norovirus GII was the most prevalent cause of acute diarrhea in pediatric patients, accounting for 96.8% of cases, of which 30% manifested as severe diarrhea.
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