Key result
Norovirus GII is the most prevalent genogroup in pediatric acute diarrhea with ~30% severe cases.
Why the study?
This study was conducted to investigate the correlation between norovirus genogroup and the severity of acute diarrhea in pediatric patients.
Is there a correlation between norovirus genogroup and the severity of acute diarrhea in pediatric patients?
Cross-Sectional (n=94)
No
Is there a correlation between norovirus genogroup and the severity of acute diarrhea in pediatric patients?
Norovirus GII is the most prevalent cause of norovirus-associated acute diarrhea in this Indonesian pediatric cohort, frequently causing moderate to severe symptoms.
Supports GII surveillance in pediatric diarrhea; leaves open genogroup-severity correlations for prospective study.
Background: The objective of this study was to investigate the correlation between norovirus genogroup and severity of acute diarrhea in pediatric patients at the Dr. Soetomo Hospital, Surabaya, Indonesia. Methods: This cross-sectional study involved 31 participants aged 1-60 months admitted to the hospital with acute diarrhea from April 2012 to March 2013. Norovirus genogroups (GI and II) were identified from patient stool using reverse transcription polymerase chain reaction (RT-PCR). Severity was measured using the Ruuska and Vesikari scoring system. Results: In total, 91 stool samples were obtained, of which 31 (19%) were norovirus positive. Norovirus GI was found in one sample with mild diarrhea. Norovirus GII was found in 30 samples (96.8%); one sample with mild diarrhea (3.3%), 20 samples with moderate diarrhea (66.7%), and nine samples with severe diarrhea (30%). Conclusion: Norovirus GII was the most prevalent cause of acute diarrhea and 30% of the cases manifested as severe diarrhea.
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Athiyyah et al. (2019) conducted a cross-sectional in Acute diarrhea (n=94). Norovirus genogroup (GI vs GII) vs. Norovirus negative was evaluated on Severity of acute diarrhea measured by the Vesikari scoring system. Norovirus GII was the most prevalent genogroup among norovirus-positive pediatric patients with acute diarrhea, with 30% of these cases manifesting as severe diarrhea.
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